邢唷>? ?欹q` 鳵鐲bjbjqPqP∩::w|><?(qqq???????$x*h?p?u O"q ?\(A&A&A& *?A& ?A&A&A&z pN(D^7$0A&? r(0?A&P-g%P-A&P-A&tq€A& 4?qqq??7& qqq?  Curriculum VitaeHao Fang Ph.D. 筫im Professor Institute of Medicinal ChemistryVice dean, School of PharmacyShandong University, 250012 Ji nan, P. R. China Tel: 86-531-88382731Fax: 86-531-88382548Email:  HYPERLINK "mailto:haofangcn@sdu.edu.cn" haofangcn@sdu.edu.cnWeb site: http://www.pharm.sdu.edu.cn/grad/english/pro_fh.htmlEducationPh.D. July 2001, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University B.S. July 1996, School of Pharmacy, China Pharmaceutical UniversityProfessional ExperienceJan 2008-presentProfessor and Associate Dean, School of Pharmacy, Shandong UniversityDec 2004-2007Associate Professor, School of pharmacy, Department of Medicinal Chemistry, Shandong UniversityJul 2003-Dec 2004Post-Doctoral Research Associate with Professor Binghe Wang, Department of Chemistry, Georgia State University.Sep 2002-Jul 2003Post-Doctoral Research Associate with Professor Binghe Wang, Department of Chemistry, North Carolina State University.Sep 2001-Aug 2002Post-Doctoral Research Associate with Professor Ronald. W. Woodard, College of Pharmacy, University of Michigan.Research Interest1) Medicinal Chemistry: Structure-based drug design on the targets for cancer therapy, including histone deacetylase (HDAC), Aminopeptidase N (APN/CD13) and Bcl-2 protein etc. 2) Bioorganic chemistry/molecular recognition: Development of fluorescent sensors for the recognition of tumor-cell surface oligosaccharides.Honors and Awards1) New Century Excellent Talents in University, Ministry of Education, 2012 2 14th CPA-Servier Young Investigator Awards in Medicinal Chemistry, Chinese Pharmaceutical Association, 20113) International Medical Communication Young Award, Japan-China Joint Medical Workshop on Drug Discovery and Therapeutics, 2008, Tokyo. Research Founding1) Design, synthesis and biological studies of new Bcl-2 inhibitors based on WL-276 structure, PI, National Natural Science Foundation of China (NSFC 21172133), 2012-2015.2) Design and synthesis of thiadiazole derivatives as histone deacetylase inhibitors, PI, Shandong Provincial Natural Science Foundation, China (ZR2010HM028), 2011-2013.3) Medicinal Chemistry Co-PI with Chengguo Xing of University of Minnesota, NSFC of Joint Research Fund for Overseas Chinese Young Scholars( NSFC 30728031), 2008-2010. 4) Design and synthesis of water-soluble fluorescent sensors for tumor cell surface oligosaccharide, PI, National Natural Science Foundation of China (NSFC 20602023), 2007-2009. 5) The studies on the new flavone derivatives as cyclin dependent kinase inhibitors. PI, Project of Science and Technology Researchin Shandong Province (2008GG1000 2010), 2008-2010.Published SCI Papers in Recent Three Years in China1) Hou X, Du J, Zhang J, Du L, Fang H*, Li M. How to improve docking accuracy of AUTODOCK4.2: A case study using different electrostatic potentials. J. Chem. Info. Model., 2013, 53(1):188-200. 2) Su L, Cao J, Jia Y, Zhang X, Fang H*, Xu W. Development of Synthetic Aminopeptidase N/CD13 Inhibitors to Overcome Cancer Metastasis and Angiogenesis. ACS Med. Chem. Letter., 2012, 3(12), 959"964.3) Wu Z, Li M, Fang H*, Wang B. A new boronic acid based fluorescent reporter for catechol. Bioorg. Med. Chem.Lett.,2012, 22(23), 7179?182.4) Guan P, Sun F, Hou X, Wang F, Yi F, Xu W, Fang H*. Design, synthesis and preliminary bioactivity studies of 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors. Bioorg. Med. Chem., 2012, 20, 3865-3872.5) Huang S, Jia M, Xie Y, Wang J, Xu W, Fang H*.  HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed/22506769" The progress of selective fluorescent chemosensors by boronic acid.  "46>BDHJLN 磙颐掸棃梲l]K]:] h郍h5丅*CJPJph# #h郍h5丅*CJPJo(ph# h5丅*CJPJo(ph# jh](UmHnHuhSUh5丆JPJaJ h5丆J OJQJaJ o(hSUh5丆J PJaJ o(hSUh5丆J \乤J h郍h5丆J \乤J h郍h5丆J \乤J o(h5丆J \乤J o(hh5丆J \乤J o(#hh5丅*CJ \乤J ph"$LPfF p  U V `   ) ?勎dh1$@&G$H$WD^?`勎黦d$dh1$@&G$H$a$gdgdH$gd $H$a$gd鐲 " ( 0 2 6 8 D F L P V p € 蜚毅毅依珪珪珪珪珒珪珪玨僕&hh0J5丆JPJmH o(sH /jh?h5丅*CJPJUph# #jh5丅*CJPJUph# +hh5丅*CJPJmH o(ph# sH (hh5丅*CJPJmH ph# sH #h郍h5丅*CJPJo(ph# h郍h5丅*CJPJph# h5丅*CJPJo(ph# h5丅*CJPJph#      T U V `    碣砬薄櫋噋XG8G8GphhB*CJKHph hhB*CJKH\乸h/hh5丅*CJKH\乤JmH phsH ,h5丅*CJKH\乤JmH o(phsH "hh5丆JaJmH o(sH hh5hh5丆JaJmH sH +hh5丅*CJPJmH o(ph# sH #jh5丅*CJPJUph# &hh0J5丆JPJmH o(sH #hh0J5丆JPJmH sH  ) 1 2 9 :     > ? X q r w | €  脍粟匠节舰悽悽悽悽剿劷私藙絼粟剿剿谒剿诮私私私谒hB*CJKHph#hhB*CJKH\乷(ph hhB*CJKH\乸hhhCJo(hB*CJKHo(phhhB*CJKHph hhB*CJKHo(ph'hh 5丅*CJKH\乤Jph4) : € sT8d $1$@&G$H$Ifgdl$d $1$@&G$H$Ifa$gdlPkd$$If杔??p n644 lad $1$@&G$H$Ifgdl$d $1$@&G$H$Ifa$gdl  r i%凥?d $1$@&G$H$IfVD"^凥`?gdl$d $1$@&G$H$Ifa$gdlPkdH$$If杔??p n644 lar s ?Rkd$$If杔攤??p n644 lad $1$@&G$H$IfgdlPkd$$If杔??p n644 la €s[L=$d81$G$H$a$gdAb$d81$G$H$a$gdAb刾剱dh1$@&G$H$WD|黕刾`剱鱣dPkdW$$If杔??p n644 lad $1$@&G$H$Ifgdl$d $1$@&G$H$Ifa$gdl€,-07?CG镝途癄癄瘨瘑抶gVCV$h?5丅*CJKH\乤Jo(ph!h?5丅*CJKH\乤Jph hh4HB*CJKHo(phh B*CJKHo(phh4HB*CJKHphh4HB*CJKHo(phh4HhB*CJKHphhhB*CJKHphhh B*CJKHph'hh 5丅*CJKH\乤JphhB*CJKHo(ph hhB*CJKHo(ph2 `LYD$d81$@&G$H$a$gdAb劥凬dh7$8$G$H$VDWD?^劥`凬gd劥凬dh7$8$G$H$VDWD?^劥`凬gd?$d81$@&G$H$a$gdAb$d81$G$H$a$gdAb01   贻仪公箻箛玽筳WC6h?h?CJKHPJ'hh 5丅*CJKH\乤Jph$h?5丅*CJKH\乤Jo(phhh?CJPJo(!h?h?0J5丆JPJ\乷(!h h?0J5丆JPJ\乷($h?h?0J5丆JH*PJ\乷(h60J5丆JPJ\乷(h?0J5丆JPJ\乷(h6CJKHPJo(h?CJKHPJo(h僓h?CJKHPJ*h?h?5丅*CJKH\乤Jo(ph  ghS0JLP-KXY[\CD\皲遵遵遵遵漶神浼裆癔Ⅰ攣mWGhh4H0J5丆JPJo(*h`nh 5丅*CJKH\乤Jo(ph'h`nh 5丅*CJKH\乤Jph$hAb5丅*CJKH\乤Jo(phhhAbCJKHPJo(h?h`nCJKHPJh?hCJKHPJh?hAbCJKHPJh?h CJKHPJo(h?h?CJKHPJh?h CJKHPJh?h?CJKHPJo(\bcjpLZj:>LNVZhjlntvz|')1筱浙欠ΨΨΨ菣钦阏闱惴ΨΨ銠钦帣倾倾欍浙嚽檣h僓h4H6丆JPJ hh4Hh4H0JCJPJo(h4H0J5丆JPJo(!hh4H0J5?丆JPJo(hh4H0J5?丆JPJhh4H0J5丆JPJhh4H0JCJPJo(hh4H0J5丆JPJo(h鄜0J5丆JPJo(,D ZI'@訞釧IC銫錍鏑鐲 dhG$H$gdAb$dh1$G$H$a$gd$dh7$8$G$H$a$gd繯劥凬d87$8$H$VDWD?^劥`凬gd4H劥凬dh7$8$G$H$VDWD?^劥`凬gd4H1;AEGIMNOXYZ\] (2478箬谘蒲坪蒲獫攭}r褖fZ驩Crh:KLh4H5丆JPJh:KLh4HCJPJh僓h4H6丆JPJh旵h4H6丆JPJh4H5丆JPJo(h旵h4H5丆JPJh旵h4HCJPJh4HCJPJo(h4H0J5丆JPJo(hh4H0J5丆JPJo(hh4HCJPJo(hh4HCJPJh4HCJPJo(hh4H5丆JPJo(h4H6丆JPJo(h:KLh4H6丆JPJ8:<>BCGHIZqxz{@ @@@@滹湓燃澕潝澕拕r_L%hih4H5?丆JPJ\乵HsH%hih4H6丆JPJ\乵Ho(sH"hih4H6丆JPJ\乵HsHhih4H6丆JPJ\Uhih4HCJ jhih4HCJPJU\hih4H5丆JPJ\hih4HCJPJ\hh4HCJPJ\hh4H0J5丆JPJo(h:KLh4HCJPJh4HCJPJo(h4HCJPJCurr. Med. Chem., 2012, 19, 2621-2637.6) Yang X, Hou X, Wang B, Li M, Fang H*. A DFT-based Quantitative Structure-Property Relationship Studies on Coumarin-based Prodrugs. Bioscience Trends. 2012, 6(4):234-240.7) Zhang Y, Feng J, Jia Y, Wang, X, Zhang L, Liu C, Fang H*, et al. Development of tetrahydroisoquinoline-based hydroxamic acid derivatives: potent histone deacetylase inhibitors with marked in vitro and in vivo antitumor activities. J. Med. Chem., 2011, 54, 2823-2838.8) Su L, Fang H*, Yang K, Xu Y, et al. Design, synthesis and biological evaluation of novel L-lysine ureido derivatives as aminopeptidase N inhibitors. Bioorg. Med. Chem., 2011, 19, 900-906. 9) Hou X, Du J, Fang H*, Li M. 3D-QSAR Study on a Series of Bcl-2 Protein Inhibitors Using Comparative Molecular Field Analysis. Protein Pept Lett, 2011, 18, 440-449.10) Wang Q, Su L, Liu N, Zhang L, Xu W, Fang H*. Cyclin Dependent Kinase 1 Inhibitors: A Review of Recent Progress. Curr. Med. Chem., 2011, 18, 2025-2043.@@@@&@'@)@*@.@0@5@7@8@9@=@?@@@A@C@E@G@K@M@N@P@瑻緻繞钷剔吉毤坲埣i[Lhh4H5?丆JPJ\hh4H6丆JPJ\hh4HCJPJ\?h4Hh4H5丆JPJ\乵Ho(sH"h4Hh4H5丆JPJ\乵HsHh4Hh4HCJPJmHo(sH"h4Hh4HCJPJ\乵Ho(sHh4Hh4HCJPJ\乵HsH"hih4HCJPJ\乵Ho(sHhih4HCJPJ\乵HsH"hih4H5丆JPJ\乵HsH繞腀艪褸覢訞諤A A AAA'A(A>A?ADAEAOAPATAUAaAbAhAiApAqA|A}A孉岮扐揂朅桝ˋ〢睞矨続繟薃虯袮褹誂譇郃酇釧蜴劓士匕虬劓劓劓劓劓劓劓劓劓劓劓劓劓劓劓劓骝尕尕控hh4H6丆JPJ\hh4H6丆JPJ\乷(hh4H5丆JPJ\乷(h4HCJPJ\乷(hh4H5丆JPJo(hh4HCJPJ\乷(hh4HCJPJ\hh4H5丆JPJ\?釧鉇錋階駻 B>B?BzB侭孊嶣払燘癇睟碹堑仟—晧~r~fK;h僓h4H0J5丆JPJ\h4H0J5丆JPJ\h4H0J5丆JPJ\乷(h:KLh4HCJPJo(h:KLh4H5丆JPJh:KLh4HCJPJh:KLh4H6丆JPJh僓h4H6丆JPJh4HCJPJo(h僓h4HCJPJ#hh4H0JCJPJ\乵H sH &hh4H0J5丆JPJ\乵H sH #hh4HCJKHPJmH o(sH #h4H0J5丆JPJ\乵H o(sH 睟笲緽#C4C6C:C@CICqCwCzC籆紺翪艭菴皲云定稐墆塴^N>-!h?Jh4H6丆JKHPJ]乷(h?Jh4H6丆JKHPJ]h?Jh4H6丆JKHPJo(h?Jh4HCJKHPJo(h?Jh4HCJKHPJh4Hh4H5丆JKHPJo(h4Hh4HCJKHPJo(!h4Hh4H0J5丆JPJ\乷(h4Hh4H0JCJPJ\h4Hh4H0J5丆JPJ\h4Hh4H0J6丆JPJh僓h4H0J5丆JPJ\h4H0J5丆JPJ\h僓h4H0JCJPJ\菴藽虲蜟螩袰覥諧鉉銫錍鍯鐲燠邵禒凵悑tfh B*CJaJo(ph-h h B*CJKHOJQJ^JaJphYYY h:KLo(hh4HCJPJmHo(sH)hh4H5丆JKHPJ\乵Ho(sH&hh4H5丆JKHPJ\乵HsH#hh4HCJKHPJmHo(sH hh4HCJKHPJmHsH&hh4H6丆JKHPJ]乵HsH 01?2P皞. 捌A!"#悹$悹%癝班 惄n餲{馃煷j?Y梮陖纋χ塒NG  IHDR{€)摇sRGB{IDATx^u介摛譽迿站鲛牨@?)Q?邑?嫋礩罅鏞p腖虈墘櫂銟pL孆?藪┹Zh歓H;絍/电緂物y顩Y誐┴(Vee撅}锡鳒纥畿s氵鱞盭<>嵟?濖峗鉸/q~ 裲鷀愕觃笙蜮?\壸明鶝肊蔑夎Ax7_烚鴏勧瞺?濰L'摀F#炤0\'嗎囙>綢4惰n剂蟜L&摀2 "y鴎>孒vA^硜隣| )契g棝N朴閯棏磺狅慰 婵賅鴔&%齮餪 t.鵽砳垶-5x兼⒀J耖向谲猭M箫瞷徂~栢O+?Iu︺镋恈4?~绷潔#S媠v琴DO1嬀敲>箐QfDp`3'?蛮o栐??,r初8b缸蓚砱嬼6f朲刺g覝k蟟櫸渣紉"娰ka2砩聦Y\戉O-贴奈t}???杭妄肂櫙腕I?虂?辋[|A鱊y样惜铪[4頷跠坩蟶l碞兟GI镈說F骠8ｙ炠摖憇7鋈";m叉X舓?Z憐%OXE 檾鑮嵯s=:=珤,饇敵 9褮H麄逎二皖幛SF>l[?耹??瓃'J骧軩n臁7固.;荰s5馔醂j4滮灖=糷?殼貳纡y?t墌>uｐN$?3=菦筵iNN蹷膢瀏#崠l$mg?藤 頖0糾.? 蟲谀淆読镵4'???慙t禉菦遾f騟2f哣槄o憉9扴省療謽0鍴3綉U橫4止xH2=?崆x秶袋鬇H@ ???踢lU>储⒒摞h4寿g9岺唊as衑O﹕x輔{镚l?圇P嚆OYU氯筦$輷亳p艤ゞ愝勺)4劗i玬`鶒@N[ 庥??' qb悅託/髶7响涕渠搪#穲滂?E.pnＢ+3=?,鱃?毎橦狱b夔~ 嗁 驒+{磶g31冋'本%0凈迥笶阐族语 碐團0[?&逶绘桗哲斖屉特?|j諈73f?G萻纒厬萧嗄艥_/掻l$D$Z?7?5郹<谰侧,R姽@3恹[D懕>e躦復UG氥+ ×靕罹鐅6\;z駌J笐h3 еf饢YvV?歬??踟池2黸???M&勫氧迷FS~甕?飈Z=鍛厱荃5圃灗ad|^體蔍幥Az牛F_'簗Z牕饥~|挝C寥x?儞'騒悯錁|>氿堽嘐塴謀歴 羧獜?S橘EN?絘v愎 弣2崇袈 偠z宿灅W^с8?6#轳x8哋踤堽嶧\.棷h熃?l~蚞鷫餲A焐奶炶DzA徖h咳O<玳嬑誫髨t暪>2郹跨國7^#Z啽y?g 鶆T{dJ聮?B祍8 a6鄩达?珲h]硝zΑs齟f"捝;u:澝儍fJg 狞_齸?漀s羄粉j蹑嬷謾3gqA髷E&|?潲l騨?辖R古傀峯瀄T?ID廐阰A簌 Gt&鄵鐪=酑f蠈f围=Mub祆躽輜鑻[oloW 儈/椣鐁筞瓥蒮广瓫7邁腠V趉?搮B!旿响@,b钡醥{赜き?泧崸p羒AYS2?<埆圑xJ "5櫕阬2兡矛围织嘔兆|掓Fcx$臏Iジ{锞鸚wn-濴ヒ㎎,椧? 委K&e燥酹第?^?\*桼B蟙查t啅r}忐 7砻1彝yP:S濔┯联 D珶O=r淁D=$駲"刱1鬾穻tX卺齼 )鍤k~駠玎:o<朚冕隷赪框暬凤t跐馾4徆)旧x"揘簋\6[,麅~卂X?蚮3澤\}鶬^箌筤瘡G岗q>_体s腚?,奢I傆猖u>?鴪3傣!岨卝耂强鲺譯桪z掹鼏链蛝膇涣@ey尮?V5慙Τ櫻l0a:獢g电髾TZ€*J焓咘楥? ?撋07>荐{_锝齠:昷帝\辷0}`鳫6沞蒁搨忎q7范G#?辬枛^}跽鱷KKK+K嬇b ê睫螡;槧纩骀R氹鸤pxd>暰鋒g6S嬽劖馔A鈫GC沋 菀?謆D剩焺 鵬<"氥-?葋ul/A薲b兇?僱t!耬9d2檩鱺镗o箕0啐n€rO&? p減cf]訕TR8cvt:鶙閡;橞aia'鸊鉔穱J桱e烃?H?/晋蛩瘆2浬騦摇梗z腣淘4婇鎗陱E 其牵?_i絘?W??€z#2p?,鯰 ()?駶$搐)厎╒+厊.旽騫L鈒劃蚫ぁ筛渃<~秭?鸰腚\玌+\凑iu:]o婐 |鐫 鹆`(>?* :醂gUU*e>葇D翫2K宮0d?iI?K 厅燓檄,/Ⅺs鉹3彜d厺媞nIN偐p灖¨$T添讄恔汫飗C,"i#T!.潍牓罰 汰/V}糡(,元Hj飔Ya*塎J谷td敲?淇襻a盤`.燑?$*?譯*迟?鄱 z攣Id?&? 愃贚硕侧<;築2晼胰?顇2澸藍诟梳鞦"A茗.k_惱宲墧劖i遐n{眎騳單蜆呤嬅d1飷鐡2fp巽z竽揙r莹 Y0 溣???<わ3k擖錩z鼽鉧€AD %m枏 F庺G€寕 ?椤呄啥劶O繬圡k6|箚.熗~馩?鯆蛕錏洙^g瘍腹"7?釽筁t僸p廐C8陲?xq繭x炥焏j? L9嶽辿<0撄 吵环??^?t?2稀?撧夐縻?E'+鞐鵚?湠 q聚崛J饰? v踻€/艇l齦軙o摟傟PQ=濵嵾?褂L澺亏飤噺!嶣鼓Jz胺琼*錼饖 i豬鳏蕞T霐外i翑K钪L猜SF鶊諨"^玌QyYgVt摃崤狖x络9(棗范?醮~'蹭'挏離X摅傁鍉z=$闂%點ЕH狫F?z?BQR栞c鴖撑c燣h馥Be龆A.鶣"嶻縮笃oн竰麞?,习XL 葆3? 饚亮4'I劽T殸掻惷?$鬌2刞L €囧€?P魆B&堣 觓熌痻1泥$^竫qiq)莂僖熗沁Lm^?疡,??奿w!B .%駻J5K嶐謇l漚Ap=?.幍幈漟o铒!?-坺叔騒棥?_扰佔E?0f"舉cAf`|$舥Qn劚l?9a婨<[E'翤I+s#酜i廸OV1櫪?踅儍}6&8>〓?嬭8埭蘭胕闺?*鶍盔K彷?c緣$E}2D-r>s?艘n?痆E&= 醝G,鍶v塆V?潓?b7@m 7殭,宵+憔??錜戠屔榏v€ 醾p, ?棇w垗PF翾═=伕&Cn@b |Y|錟,?匊箓ma∈糔癵X?? 4腃z)隻10！恷晓蘖?A?鴌 l?懽捒鳮WB袌d釭BUC恎犲继珺蚾TLM塡RR旼N苋曺#"晖KT褜程u桑ｃ??蜪f3D枎済卦?h抔 ? 盔K袯朢葹?rｉ`－き7@煮蚭-lb戧颸{盹~埰MЦ?抈L芿%覚,妶唊殙!-鉞? ’滂 E蓰挘劼?A摔?Y衾趩<4蛝饝5鞡跪涑蟕屿1?f!昻槁秖 ?甗鵡 锰潠唉沁鲊d 压b腙卛禯f渣榵璸斘峙 &$m瀍Ж攵? ' 2縑8,1@昚郕*塹G囵S0W94拋墥轳芰X? 包sv?l=0盤B("掸\Y3+M椛4臅 蒡j鼞?剝のdcr豕Q@qvx紝偼rx?貔R*瓜3_佔Q侾2懍V?O葰K拲臙懙Dn嶒{よ^軶Tox瀸黝輢澐毻唜朓柟礄g哢$L醠Y丁质庺更@B呁鬣懒O1榒臙?梾3煢)椲GQ€螈硻O揳:A??θi＋吸?#悖?!擿y羣匁J鞔鳫暲润N'闵虺4 S弭}塝澆$ib.n騧 婪+~0遖s蝳?k莥5=堾儡蘟爮鲼搡x磌? 咾d4FE)?塶壳+曲PN7F?LVg姍凔%握?Y惃,妇孼,1霢M铭膲?卨z嬵+癁fW?6m歟P%f=氠儊槙"?\E?5v 蛽鸩謳?AS瓢症臹:齆ぁPEY鍷 姄鼨`.∑n蓁v鳇F细蛈驙:F錟9d員姮檢c9靾鯩je年?昫鍌?賂I鍝墊"V衰硻j&UJ'姪x> e AL嫈萌U憺X簦?€K}%而~|t,絩頴f7@衇懊xu冊墆 蜢mb? 嵇$〓上槴vo蠸X┽葲[薅Ez=嗉皸胘?2?拞.^C.x池7_Z岕蹪.喨貴軷+姩弶@#8鄨紪}?O2迥O , 睳R塟1[?棆俚ra1?$c錖獝垜慃亠竰[(/H,葽^莰<#*?B(覨P,}?j q黗嵶rG髣V0A 蔁象壽櫳鼔钣{鬫 @2倉糙!葴翓`??鈷"骲湂X[酰?65觀榗艎2' -V呝pL騀XZ靿峁啈掂s &泺P炳鵯獝?栻薳齕)逯*咍卹-煩宄B欆}|淜K$ 鉰XYO?,怄粰I?W(^}阨寙龙壃譤,!Nq怐*G覆喘箍遚S4p畔慜矫bz脜d84$枌,庞ZＪfi1(sk 鼸 _V攳g齱?|}^粮!Q燃€欳n>樋愜嵉簼鼣D蘐j诟揁槡M'潮柡V萒畅j6]J浦蔥嫊錼q盩X 甩 $YS搕R Y軧m"6-?QH.錌Q]L Z?枮~龉(蕄艠S軔9zn榛2埲 砒?闦垈a?敢L>摿.H莔R篳H \qR]$D df暼膆侚筕椺⒆滾謄皐镛wxH%?锯?豭E;裂D圣F翤5%b麯f)>峅a伿Xj狾寿d-沊-er檯|z躛Y(&悭|簶K鐡馼&])@8&?諸| т1O$q檝m2緤bw'弧?橧_}^摏遍銉嘂 3~桋贩C鸇$D?巸?慃娐;旭蟱{齠?p棧1牔? !x#(?纮孩m糘阷? .q竰塻?闂WYd*d+?紪盹?(,窩9?獨??Fy奵腦/棾 咊b1]L'? N矓I錜1Kc孪#湀e)萴饨憞I ?=f浍枓?机T :3竛豃偀s?ozM?7#QE[饵鰎变??K蕵?厳c欒缸濔儓'?* 钒鶇!i∩赐 V€鋦9?灇涿洱.L酙鮿飑Y綠 o廁幧R+<覊旿~}「X?痴B萒J鵍罳Sb毸摄6?0_蔴騃9胜啟})嶣$m'恹7+?~I奷&鼬诚3{ "鹚铊积d楚xng俻-賅刣洇?洗郯矤抷鯜聚瑨 }`$q?) .8x憀":M6@亱?=$旡剡莨y]/娙趾 (賔Jw?吚誕鞋#虉腗?桲箷j畾OWs閞>]萉謻(鎴逃襙s磕p8VDH]:?E?甯S ╲?'昗哖 玍斏EF冓??墈塞 萂H毋廕叴鏦鈻~+ 蕳O 碻?`{sKIβpZ尼樅飙i浒浲x_∠,05貞€4?澦s E>4图f亙瑫秔晋l値孈訖$v|Z+Ｗ賠6昁N l:斛嫷丧銠扲匓=篩狋X爗筊"+炊皃nc灞弌-]Y[X?櫵礈芬矲?髥伺:?0搉!歝&n?!.徙`龓=醅?"蠤Z)E9N綪%€揦噐C态??w~剳擨 €炨鞦榧?釂杹?!詙"脌2,nmx 玆?.堅AK朢ST夌玉b乨髨v#,?\?邇?QD€倈蠺&|?0C_Y獫;出溴砏/瑹_猆博祭Ｖ=f9鍧"(唥V词M滮碫萷K粷`??bvpｕ蕯KS壎?騡Q爜#tH?Y?)V?;饮厡詥楳蘄凖dF悤 幃蔞r ?X锖┏B` 詳i €湌\坜貺喨嶨艇馀Tl1梌*?H+嵼姣8C,#s% ?}囖@cM萜披?Pd毷_獤戍2V墈賻P;襐0?(y<<<?湂?P掚晎搵 ?j2Q饠?l瑨 鋷罒b??a枙89鄗⑷鋌?J幚勥E獓d摯4悞)KC"!岸鼶H~豌<_>5M 报v窄e?b.礨蘥戈p斍h &抲繀恑S$陳=斧`棓3侲鑦Q譸K軜樖 躓>fx)賑[~Q?~`W絤%蘝萿吳$饜馊t颂?e有?4\, =烱p$7B缳攠O鋲;蜡襚Yz藵X1夒A拋矖麜憦6jP?踀8惾鉊E迠[T"?蕶Z:羫NM&呬t玓8籜亘+鵭1[师H葶M<+R剳鼕[A嵥嗢/銛8?(d谩?bkf9k摮qS斄樖7H*ri7沚萫銷挖蒫Z機?AE€Y\?隭O夣奪c眥鷜掽魪鼊?鞊頗Z06?檊諁z`g;H1衂亖聯面?u)雏婅M?踍疁?W嫻時钐r趼J迓jic∪_藚|`╒蓧築 F)彵躞0捸1u 崬?(范..?╀楘葍f嘝bZ螖?q嗳f蛩玨媖[娊鐣}X蚔Vc?+0堽?禮c?4Bp嵜羠Z战,彗?錝鼇q贴O畢燒橃0E?椼J:[?T軤 嬳 ?郆'd暵鯮轳sK缱kW/籼箯?滨詸ン+宓JnRX叟J)錪 UiK??鋩冖坤挗覵D歽丁d 蚁堶络C熍)宰≦C,歊?衣?硆抩奺 糎b+嶷\AZ?]疇'qq?晰薾G6=鋯坁D6R阽I矕*1pD俁c勳胙*滄]€嶿T麫樂啕?鳀蘦?鎡$ ⊥B!SJk峜:蛏i>瞘业|盫( 鵍>W*銳|螦檺)泾妳r1C=K捁<儒 Ev^'6羯larC齊捫[畂<〞r埴KX `7瓔 ,(轂Q€h諭s'FX>y[@I=攆扸敳=3驇%?踬梞6帞Go俟纠$?D婀緧潣靼骻?B⑧#&舼v镛R?倌漽焹*A衈*e+纉sL? &〒ｎ偡娌斮嫞`隕!Y刣傇楓€」*徃躇 ?$楙楛R?伷8:SLB孟F阋蚍崩矤废炢8?奛癦%?騑?@f扌郰(訌RN梩h墖窽 /爞&蓺B磐账瀁?璃 \4幷囉 薟迫触枠EL亙}慏碡 .k悚粍{?8?OZ妨?詫尠52Y舑cpD槬b Z蒮t9_L~+"鐭蠊]S睕+賀5S*g?v11P _^╘賈购Y;[藮J 埍pC鍨+゜OLE@m澚儬B譲鹑?坾U鷄炥fZ' 藻 2` ??pざ夎 Y訫騫4R6@<庋D珷?饉m麘籙?>lれb `>?叺尌鶎r*`aU?佡?A贡QI瀨Q6:k,(匌.数g?哆ow{?汵T嶴VM6NH沕dpJ檤夝墢时腄彎]{觎蔤I?O聼tFyYIiJ厮a\!阄S蓑Fv:/v砃t釮#藤'~鴖B!怔>l襽qSQ&`飳珨Z諮)!w7甬WJ$R堬?u墽鄱海6' 捽庄盹辸8'H畖忥?疑祌H蕟H 9j;御<箎灆躏5C歂媭乯?VR再 淮撿]纷i5[菎鲠罳Ｕ=:j?訆`?砫儓XQ?(察?8n鮭崥T)鈾j +轐が呍5/i?>q唨轳" 伎咡'幻r?_?/?櫋??韜"赠zq?kf羴婞?弅$"" 疈詘)屇炝茺铐0z詾4^e!桛縗Z)?SD@h1曂炮b綪B躂謱b僋O(We+=$;顅(_09?刵{L?;屓f懙膂w鲙藁~絻o輣脍哇黯o蒇絳费hdssL扸{倻&c??椡u劢?先*Oy?騄Y?锢赯?筬簸c鸁Ｄ嘣P`#困勺>筱hl鵧嶄岩3鶅*蚀wmDS)+g兵瞢燱炢躩5斓[7o|鑠窿V萐啍斅フ曩%v慙 D舑笖:貑鯼髁泽揶犷醓濣,d'仠}搆H絿6;韓|}堓梓v縀?(娌胇棤频?|c禭TZUA慾硥轧p!に晓鴎/湱UγN?殾渃 尌Z醽e槔C釓u6'w侇7荊~?Dk6銇綋媢旉-敋W襯.$ 逸zAFh釘赁嶋譈う汾P.驐Vkgj?瀓亽匯┎ 劰y}缑[;w钸縴甾v铒镒;鮢焚?kó苢tC1p椩J珔A眃kde尜帟藮虬籷€瀱J3婮鯂一B!tP哔;?@钣廫茭鋾暳瓀蹉I"}8!&Qj?胿l娭坅H€慙咢喯?J劝|鍳迈 2+*呅8怠怚餞炞甸fV牣\蔰?囮馓?X11?u{穙\堔?綹.<侗竀脻bO狵嫲h邹縱闫蝢粐舟G餓t幦薻趰T昚乍?E豯`$膙R p宓T+m./_緋雎雇靛叺啕お€殝'_?氻kwv塾闹R錑灲榢靰祓鶱im珣蘍膖Y鍰€Np9 1u?hc痣Qq?GJ?c谢袀 r雕摦M畃,橳?膃履*q覎G`鹚辕T`雹Up6?L13 o稾)諮y?d篢﹣?x髭交籃 跇摔*夈臖fWC庚fh隡 烯翾丹尧*b騲V靈賆Y簍v俏?vi}c璟抬J馐b壈獝?粻cvi鉑韁^{媛j|p|ggH镴綑佶媆q(J+TtSX繫耈腑単J4hQu燑虖)茥?B>?舓麹 9鶃I浰?yVC^.$-E輾X嵶k咑瞽:鸑d悭 犜薵窒婁茡b筞(栴遻p|岳a猁亚嶅手咉g.熪豛〇!腨>蝓鳴卙硷崱8@.fL琅訿d覊Nt翱`Ti%糂當eè9u叧奜1-{籊o]坏菇艴q鏿〔0?Л钍 峾祽?蒷e頗H? s@璩+/珲 蝛e酿湡 u嫯t?.3驕聄藽埵拇a剌9?)9Y#讘A 圖弽7椢7Ν;護詛??櫢唇|巹鼣}汭?q? 藡档尻蔮euuay 6厊&N.嬍籂櫓宇BR綳€`I酮|UH/痘w鴿7o峻迌??o芫s褙鈈M毩矀? $蚮PF蜢蘧K蹡sT方X璍６}禥ZlhK懝飕+笹垠悁睞X钼]h?燑,溕`L甇I(按厫^i 資 x陡3D遵琏`氐 扑?€痲'匛油i泐楟 vt勳峼,?6=烤tyu)胒j屈疦<蓡禕2玄>簘笃籵猃o芎鸴空辍"s匌MaNF誶ask昮楯*嬞Z8 ewx珙尬aAoz迟?尌暧钩踳鰊揶 py慾朒"M\E?W垟屋簓酶\€1潲嚟牿箊≤Jd雰a%h,&灺g賡)糲 钞f掑硇刉>?帿:猌備缁&LbK絟q|;稕卥拠w*獴e(e\€V~1OZH F}霉9 盂譶錡鰒鯴拦Z举ィ曅溱b轵沟l|烥?\N帔伙齵嵇羀wo>h}p0xw犧;8 #T躷翰\圮蕃牥鉗空V蒨肯p帋[墙雅K梇#嚁幤舤鐬?d? 鑔:榹2詎铰嗖rt冄桔w煌F咀夨簱^痋)蹪羰趹瓓x\璙?H???$瑷-泜)g彀藬绘HBh殠媟?mB馯巡裭妅嘂Q龐(M%q?"9 b嗶酐龥奍#?f眎m馄燍魰硡4丗D鑦B>嶷7君逎澪$^b┿K昍2裉笙燤{凤懧d?藯哦都|驸櫴Rs埸8淞淅弈抨v |_犬棆?t跻X鴧蛸湾?K缥lC}/.Q实WＴ!W?箴屋2⒔Y |N?ó軓坭竤是?蕎?箊. 榉泻湙=`蓅b+萣鍚r偼nG|燾r(捹J濺鉈侰繧$偅!鵦I\I宷>1i吖魲7W*9?U~-諮W/lR▎厄d疅熮莨睑芥$Y猇譝柺舼д骊KO?^鞵94/?X 撗r壕 [EX躮4欫kFMbа剡??N ?v嵘媅洉耉﹛v箆ym狴s洉 枕2双张e燢e^猇珛5?櫘a稢饢H](禰l宮訹uQ犠氚鳮裘(^?#) 谹j?篾y徇樇牝Rviug樲焏q*嘾H昐碄U蘣咰沢齑壚2E鮘?癫?骙t?堅7鼡蠺?礎猆詪~I 撊?.销 E觡R#FE軌J h睊螸頢cox莒鱶维]轡蕭 燚僼D共锤p嵋稣窍S殰奦5闕鈢p詊鬑9龊<+?K 晘獻%"耛佘L濠HL芦 e濶H/6-r臷庯絫婁JEr?獖摹翪∝<Y$}q腍PS2敐4踖*歐WG櫬蛜瑸葟ㄕ瞈?D椤0.Dz(`wE笘壴Tv(鶛蟶N汥,趷 a搄#f?ZP?U>胂蓽ワ嗀\=炭86淺!桵礠费n7阭1斢)[&袭/%苆OīM*鷢芺"〓:t蛀獈~H樛鎩e盧㎎ <桃K號┣邛皍gX 咈O`-Ⅻb?Tj 5焐}礟棥嚇CvAyc猏惠4蟲尶n]綥姾浫Iy晌XN袭骡睗HM-瘫?\鎊Q庛}翨孷敍 E,i千!s茣]=營>x锝ィC5挱Z€1 厖丼]さ稌.敇z拇%漀惭轖痪敂P醓v;趸旂u資NF嵽O?n7F"!FQB?i鱝?1觠?/犴鱕﹚筙瑬戱侣率谑脐檷?排Ez]惉S? 畞::|Q拿饑泠椵緓 棉m?波J0勾.bFT尻mJ倖P?P螫j2酲╬滭6杹幉k嵢0~ 匽f愝!劊a?煻岔 %哸捐?J觔b拚0鄫颐^TI+颾?砓zfBR拎L呈b荄骴) ?栄 A憞鉐襜oA&!?V坄x 6?鬡%[=焊 =EUk克鳋#(FL弇⒎駃摑;$@怣R9摚 {二?埛镻'?#f^>,v J5=/会蓑瘆芵#?措I?"jr,筆M杂Q/s冏傜r挋IY颼/ZS6咢j荊鲥諱犥鵎缳獵e陎泒繆旸漙X祂0*篙V?竰黯蝳;---桱%n踡5U瘎e犪R蘷￢叚}酋fDT$Ｔ  %i%呼蝐j?8泀"齨}符I忾=阨C笯XV桅卂e甄^讯谅1綢决㎡+IC?渁娾{粠+i欍I菚Y萙eH6?w:bk?$?蹎K弃b凢熘y(駂 :腕B"q寠<9b原鬃Nt溆恝忀F玗o臊8赋s愄?\篢*倸漫Y磃戡籽dl? d葭貟繥a衜?E.?辊+礪欧R呗^ <0噰葆;鮝+慤"&\聵X`軃.蕴樼p0_揱`A6耹?瘬ah啵紒J(\I8T;鋼46佣J蒇D妸t 抲(Jt墨幄@乖t-#鍢)柸饫櫛慫耐 i诙矋\厀2=R@ 垉凓額?M_竢舠演滬鮟$陂6!!S糊V紼?頖r梃y8姛衧韰0Tfa騮?閜Q0誮鏷/輸篮5河O頛3鉚& x(o躓册Tx磠球^?崷!瀨鶗O笓?4l=睟赫{)?罌鎁?媘?%v逎?X隍a(滓濛VA閠)沒_[D&G擙?俿厾(釼Fg纍[\Bl5弾{噸*?方 *傀迖譶>豰鲑7笼麢n挹藜y穝澡譱R 钇酭O鉳I??{VH 鋪€ 濄謨敕隚蚔猺3憃&骴x渽p怚\pC弥C鍚f%鶳?V緄蝻|?韎/0?qD￣蕰[?v+(6鸇(J 賒{鎰Z呪芪压!~gwH-[t b阀曓{ ;X}l鋒u鶪蠫T_|xt睑碉絳缤葜}fE揳d:)M¨b?€傶蓡Zm婾Uh猾N?(S譄刟樶H灯懵Au鉵篟Oち 妩~韎鮎瀜劼?鯶卢??:娖跚爧bw?|戾€*TMIr捁個 異懦檧@刘-丞俳B鞚d&sH溴???z傼寭B緮滛詿 軃硵P哺辖塪杵J篵镳]?唼)4!鉲w弪;鄗礬鈓? K嫶离慪?:癲xnwb ;暍偋跋B猶M峉w銜z塁?渫}-噘z? +?绵a縷d椠I豠?孬痠K%B臢qR馐o囵儨燀?觪rRMcp6讧竩?尸+鵶r?Sll啥?IJ篅o躐t#.Ac|錌xQ?N豀勓圞絇 E╉!皐緪uW.搨Y綬*€鋴怴?獕u?>w鞻\狾#k绞.K廒'棲徲幻D*х,?F9NW漦5p鞊挺J?S?t謸(箯緿H艂譮 坲?q颳裫蠦 竧吮R 綿謱桚叾猵~6C堧Qy樲&H}梴鱳v鲼+双榷蹍3彙 贬?\?矵I離A鱠F鐯聏m顽6#Ж∶ńウ0脽€nGG P?LR瓾緢菴鋾躪7欇颪鲊叁刨.X1f揑dF6 鎞满 +]锻>hO銎釛?壧S蘟瀗F_勷4P'亾rn&?=?!籼輂O睡様?鋱舠焈丮m鷫2Gv簐万亱g﹋枪瑲D5∑ゆ軙2%禮#i摳€孜骈餁Ozq"骂h懵喰`TpJ6嬓)蘷Jn3L峌Kr嵃醂蟒豒戞(U<镕({G菄蜄婛俪oz獏[a9魄夓n/q0&錾h%鑉脋3)庚 %?Dd忭!C镠圡[H5嶠社^|1鬗RAb斔j ,d近〈?a黼踺J嵑籪蟪B+I ?罇(=鐔=G鹐傆穻?}%瑩?  枇|馽<什*育纒e!??L辤擇雏孈€咰R蘧G諅?HJ見n4殜楢2@牲?諑逶擜&YF跢BtU0摝嗝稈P饊`倈伴C?R :V7楕筥J氷闐詈篩茽蚜帲? 0綅7x?八檾W\$?虡籒,澒=鮷T?桻f冤5?黠8蜓P€'垹[嗣yTj絵m、x|@ ?A嶁}腏#D?攝炮vbu徍冚N7櫵瀁[豝(嬓N?!€话〣:K熪茆{眙A?p鍼$Lz€ A衳轐n??\y菋V緛0秆H\燗?M??睵缛k{嗿ay饂睽kd#绉民"F怗轮\硧J[L!玤.j@桴&撷:jO鋒谰仃?箋#?/V燙汆^迟?┛?!柳CKZA9揀n6渐"5簃杠?珯垴cv)R櫘?*W3課*,J%牍蹤n獱%鍜敊E犼j$;$ 敎?/豧3恙=?p侄:揙}萩膜nd谙@=n湚#y砺3溻阐遁N3?Vvk堫#?cS8踀璢I熹T> k絭琡aD瞭D阷墚菄婍2藕≦櫄唻z檧p鸊斫z徽'=嬖恅尵蚄礵1?ぷ蟦-n瑻NRM衸ni椹砱话菇E鳑标jq酩U]g飢發#-S盦2}8N莁Q罃z*%*T%辴  w鍙棍Q噅Y璴=懂?兿"棹mDs骿S,r踾oF?峙喉$岄Y#PcP'銵S敢遹U嚠JO檆T懅蝟佬嬥W癩妽r觖壠n贓 >U波8?R珒朠q⑦"~e +婯KU? 諍汖盱晵卪"蝚q拪硲 RbT舋df爣r栈右Q蔡鋰EvOJ覼蒍坙?ｍJ搽^h>T t( 錐処Uu??ミ檶S淛Zx*- 跕?I] ?;n瀓U梗梬'笽叇怽笢Ｖ匑B的潠oV耟P i7 o8?s絍敬緙iqa+棴湃睆媰Q?cK夓呭蚄霐?癚呣A 搖σ敞岟⒑y3隱 嶿燢s/Sn%Kc* 鞪薝_?=鳅Q-眎 =剨%t[罤軉?|仞^冷睡~偪獧@H€k ?塤組Qy;l卞{mSl寂?篷艭吝:勒灿v?1?u酎塢熊8?5靹?e"齆G钆k坵;鎞礫YI2H鮷娂貏\I鏦k 隟? 藡4蟥癎+鯽7EgBal>='V??7P]僞暤e}?欕F賀堗 @⑤l~怬 眞H/H5 s?濲R 鐦?C毪C蓮~煦rE耙鷺踑9fRKV?襨坐曛紡!憁6+?縀+嵵!Xa xe?鳱瑶u薖铁鑥惀cZ懴伿纓櫭邹2到Q韵1!i踻霌m鏕v推後侈"zxb<籬H靃q^K 朁慲?犾 寇J?K媉a4j沟怐 V|a2K釡^rCP璽快腘HN(;*cK|繵謦忌昣孍?-運癗參P?踙]羀X釸R蜖?貗鑓v1嗺c鑖 w`T鸗I粙劮k?m霘b+酛 J 谷y歪把w;嚱頰炕譱K鞹&壐%聇*?瞝祽贁tJ4乓韙?SiN誏F$G攤廐$衮圏 芐$撚藠熋sI蟼> 焊ㄍ鍳s瑯S獣|殄W鶅荽Z柫埰餖D. l挭"?>?J掞pt臌+,遟賤祣S9磻撝乂?閶怘L厥6O飙]朙K饟7G蔅騑$?牉d:Σ?u?萰S趚m"e蠁5?#衑HA傃0敼鰗R#芌g啤澯箮顲.M鱿餋_6!_蓕YE寂RE蠤i夳S劒/摏娙鄅簘俍狕D遆賒Q亱"鸏/ ?7谺擕it毈癬9h籰^鞝寽? #(Y髃??彄鵳S 兔轙;??0潺T坮a鐘["Pp媽跺SKTē橷鍚JHヲ嬀儊Jv廥u翹鐠晻V,候9!.?%YM輞珟靦??fP猾夿e焚蚓yv鈰y痄3窕D虶饶?N? g谡]yj"祏勽T Y['"?JO铔嫙cK勾莒%第剻№壧紲鬫屇c讽?S穑r-'?玑?(%摧Bu紘抺?q畁 ?胓7匽A &偓軦椲绔 揬e縂8｝龖ZJgC箾襘痢^樁暣峔孋4r刐窒f 凰グ_~嫮V爭徨aq鉟W砖6W抴罤-9b匙V橙31*fg嫮皋>?( {s◥欠峙)淝濟h?€尠籁侺7 蜶鑓拞 炬M別$e溭G埜碷 ?旗窸e<j簴??y鳕雨r`嘼W供桨嘡4害阢敍b9v4抑R鹎僧怶饎叴讳 擋C/﹔垒RyVt迢E諤爦)S?=河鱖Y鎏P喓Кt┗筡I5Z鎁9~;T[|k.= ?Rz廼竼Yh 劑蘊餉'炟鬍版嫮el耘Q 兏T*U﹣徼?玎N再Fc?D]k6泑 -l?[糎? g瀤銎谓恗轔齡z嵣嫠葏n穅梗S=鈊ぷN消覃|i?阶绱M qc 噝~涵P顾橺?呖蹑恚?鱫輢惬}煯 黝6闓寜- 赠Ky?胙uf悓壋隦#?彜fJ钋狺?=€€E恀ゃA?Rr?)烑&xC T??"N`RxT欻5鋊CB莬20瘿 獚q叁G癝譸Z,Sg>l獓嚰簐(8?裶X8€@S猍R8ZAv潀\頑%デ??q籨⒀聿諟F鳘汿CG?酰滒D?曄孢蝱鲝.~煺+W>驆?s]贷碟掭箇M獠sg窎獪庭僰曂ja C%€濬俆ぁF媣A摷慖a霒vI?獌f瞍 萳R uV{-iy~5欷F媘蠋橻动飧HP0鮦E員璖&踭1舤 ┳堺mIㄠ著3O}ざ$tJ鎲*Az詫⊕G切T鷔v捺悶鮷G囋mq?訕"&歅Jt仂  毉]嶛$川楗寕Yi鑐=瞭偨鰄鹞~汩梌YY[_a鉯秸;飣醌_zO=v~墕筶QSZF诺!*樦tnY;Q偟@Ai陇?澃垶LW_廓X卽皸?璈肹搆n.=晲幈J*学`蒇CP殭椭?漽V恺?a|潼跧U?引2购梆臅凐彷雐xV?綅麲8t婯b漽暗:醿]w啐艒$BaZ(雔=#H贬旝俩?K彼扄O揓&甝縮銧s鳄譤z鶕絻啐龇F\>J/稴;錨緦-蘽{釺胃sg#鑷hF褠P痾裫p竃:B屍?\W{ ォ 錜鈸礲?註c*XT爕S敟)w陯Ic 鰫=蟂l6K慵dt窮棘#$B/Y?6R 併k嬚＝輗mi抅&+ゆW!C?5弬鏼?%劢齰鞲ug縴簋颀c鲼漿囈F冩7T僐0锤Pf?稽芽L煉W谇c壢0!鎻晋juyM晔^┛'r呑絯髌愴Knd4)'住眾阴螦ick倘な穔 Lj{,?'蹮?$颵"f#x釋d唍?縂1嵔??榰禓?欅Sse5VH耼辣Z嶪莿^?G?j暵催径紲{a彾跣觻?蔷S娔?A局^H:%z餣QgpvG霣и▼炙馩j?KKe贛?銉'扝 ]u斚ZP庆R橬!辖餋镁簊姭0a?纂鰒釗i傑挤翙fu阕B愐-v鐢ah櫲礲o] 赑簼n@憽摲狪:vu峲:dM@~襝SF]|F谦h焭#cUmT^?9Ui辰\~哢傏Ⅺ`!繢謜?-疦?挱宻KT臧鶥澫J頹齆~M胷P茷Z氅杻Q焈4f蘶吓吢鳅缕胀v墇qcq吅淊K' 哦湾L郫}?窒<针易W瀸S邎{爮YJ躧覝嫅?Q~襥枲V?$? 厣4蚨湔g潤咋?aM遮惈v[鄾L 骚Y灿.?誫y光E軆?oI昂8 P7 ?錯8蚬鮠魁逈铨鵆焅佞G胖 柛oU摪f<6" S錏壧浠]+kpヶ产龂 VK辊 庠6[韇詴I橚璑H鈀倾{镙/=鲫?#??穘 嵊fkqc暐捿\[=噪?皺V渟艁劮=?? 憒隀缭?攩8<鈉诂f瓼kR→? 霖 4┧?芜s痑gI誹D岈/匫j?U嫷蚺碚'/州冦弤?a禌锝5l钛躚@Y?蓱r8?肦场煛姽 窬欰塧?駩?廝19＿u珙輧积嫰O<q属釆?|骊悱闷韀7?!z燙  鰷X条 ?O<璂$q蔆Y6掵鏴wL纂Zv沕)］妄J裠欮甑睲: Wg堘t?;赫頂N謘v慕M珡淼蛥b>6H:頬抗s?9楃€ 爩羗]隀淆fｃ狺R1{跆?珂h{悁劕厛躳圕Dp%責@纅读呂:6R潣??B婉轳B1R舫K霡 乭 雡铥噹認?鐭z鯀珬?憬勖;胒C+脟垑>鬥n怰l耊?Z贷钾顄匮pTo?K辖鷻僋+m@,唴? +P惛↖锃v瘦z藩|毃z8v7P祕呎3燑壙喟G?}W磢灻焼? 潏?1胭鵠 駇忰壆k?鏄z籪筠螡轁[配翕jeZ陻Z ｌ傶笰`饴q?T+歄-謯C 篢锯V??? U勏0QW+cE熪Z{嵘藷cWV 橹頯魑?Gt蚶Ja?訷?SWR3吾ㄕＧa椞妿i折輳}庥吊婫-軆捻$oP访? 娞O找F遴帏?4?篭;??+欅兠媒鲨渠侬瞥e*p1b A?懵I禁蝱?UDN臘帥}t钸F睒L 栰ㄖ?Js捶t痭,~蝙玏蟤r?E.`怨犩?2PL硭;9梠EHOM[e釲{媡?,倰bF*邂g牝ネ嫓r?>究硔玣髁@?聝|W#9?剻薵侓K奷6蟣@烬?钱槾搟p瑕=rv酦睕AsY$&?蠳+LDC*嵅1粐禽;G毛燏￤~臾瘆癢午酠zV6勛愌N:澂鱫嚃c&? 胀鍏匯6? d獷汽獵趍g庥舝犰嬉媸"鴮欋 轰鉕??Ｄ迖cL驚 砛斛.嵈涚﹦Q,U薵6V怨p祮邴昊煌脙悖C. 鄊禯!鉨n5鈩轷?.9Fz"W柗段=令澼9濸眦酄笻 筳砦吾杨6伇j澆瞾 )摚& 但袟h瑻+碽絎?柉鼉_泹无A痋缺6}盧n5觇9崔y恹鞬:5B烗蓌eyq甭搛绩襏`|g 擴咠妯KeM╣疷围謼.a?嵵囧矗棊>恽瑬憫肨狈礗t[橋榍蝞^赯笲*帬j7&碐谶=趨y`霠辧虼X医箭杒b蹬 ?鸑QOu躭V?痮]H(熎櫺*?喖accベ忀刭M 庴)拨猋蠻?&r恊禆剗q%濝鏳果`?-@麟鼺|?/\爵觖窅2G踰偪揸S絈)|鵒盔oA傥2幝了 5N絸 Rh燶 郵[觊>媂m孌櫚撎_疜?伃嶅张j蝰g?偼Pr>肠垒駩aB匓.鐁峘l是>蝤単/q蔾髕笑|$M8v羡馍??鞆 4颫P??l$啋涒b鑂{軡n澘z敀晞?珧拂庤8瑆&鱳}x\嫰溄鈞%稆,Y}礆?萅剻b4&屆{近贄赉?鰮鮹x8G⑽f蜥t?9车勋?旷匳缧g慫Y9/囦臦龗峦衲€陔堘裆G4@髱晬掿B諢箝鐬髁z>呎?\U\AT互 (浵B)|漶sOn/缜砦两^堍2垅幡倬G泚椗9c髁}虉ò =s E#顣肔€甔晅[οz{擷呒r灞'ら0l复P>叁礢pxT飏k r釆?epSC?尃U萡v4JC┳ 蛚鱴P|謐?葵>郑譴uG ┤Y?#)6}晔?掘W_W啌f\=殔K9謻aム詯婠魩看龜揎媈?s甕I媦矂x?4晜vo)璊瀲"鉈zz裉闗蟐鍗溽屋w緖赋英f灃跚ue顔Y匈钔?€戨鹾蒩飧╆斨(L琿揠稑h*i觧痥o co`墭坄;6 礘裎蝳〒呎騁^鵗布铡鐼ｚ騪~誈彴髦n煠S曉j搋Xy繗蠷KK?誁撃 ^沤煽$閹藝9棹輢Z]Q<傣赜O窥Ｇm`?獒擳V猤1\ 蔫Μ攻 硾Z;?<覽暷黼芬綰迉悆][#o?馣砦?+挒5+8宲(╟ ?磻婾偩?s涟癓,>檂釼霢旙～吸v釙鐭链鄹u絳p釾?k ??ld娫H怂?剼醖+锡v鴎5豔-^R|?fmB飳逌q艗?虘$貏L#塕狄凗埍9?2觙f祐鬬?I,.朲蓥'~颛弖?[g唲?鋽挷泇划Q:笔s燒д鞬窏货冚?,妊i ?捲閎橫)椢畘氙矿舟堉?#嚌"脜.鴟L蜴谪鸹Ey =;[犆圄\J_漹Zm?zl魟9;欢3O煰癕l拷s肓瓫GGG?蕵 靚W2墙甯U?蚥満gu澄霸@魔f1赣~O?H?'-畑渶傼湿磘n庹旹\q盭陋x](:88j硥炕_9厾鉢?> 梢:歖代`?+錤\暯Wc`啌芮??櫷菞V羾譶U*+祯b?擉%&癯 臦晓栈@鷬燭讪P.Z緶暕M?Y↗m-$k阺^[w奁阾5W徔邪X黉~駲W灪?槎vn6钜欎竡tDol 2?;寪T沉榚包$N?i邯硸 3Bn?L仟ZUX[??渖L戹倌'錻繊n朥bMAogj突粰lj睚矾q娨G?馽衤B?峙8斊07w她諨馤嶜?_斋G 鬯;7w戥1蛀灀k>lv狲@kW蹲啁谱>x鱙hS钲竄钖@ Tjv蠦廉豓歂逄?疴p7 誛覔框s`{k>羹!R驸:nK菐(小o0pHq,??2R6@仧矪旿S円奓R頭篨gN鴴OV扢玘L?a?惈 %匀l霞絷?-%c#v?H怜"迪mx=竪瘥钸?閪w祹*睠%Gb?Z犯?/s燏?n7蟏嬐?wzIgr払B3}j瞦磘钍毙蔝x磥J雁Xc诺q旘+X鏂?iX":昲JGx覑q劝04茧ó搌噆€+bY?伦'ULZ澏跬臞\囙eY揚谴fD;暐诨筑啐菝蔓4?*淀e滉鮩<櫲V亍C餱Τ皉鶗顭v掲Zｍ乘恚蔟牝2襥瀢衚旋.灑竏g驀訪堌惉]胐^)l[ズ鳤黦hl2G蛅与誘]闫xRM€泀KA豀??@%B鑌Q# 6wＳj咆(姪隵璁蟃护J?Ur.龄６礧儂^ 叀鹙稟Rt酳╅V懾r膟>:朶K -ё鴒蜎?聵bA媃V靡BFM ?阋*枬VP?r4z?駍档禧G濙曏b&; E讫N媻? 趩r溓F1凉/;o~o慶A 2!匬摔iT爛[ㄇW[皚╰仉?>◣*U斠鬁缐s兤浠嘍?仱J0lg邊R滔─耹崁:O,掼?M9<^ ?卯辒韧z譠貧M!橁朒 A c鶏饣蚎扴脄焥ㄒ瑐~<絋[|颷o芫~絓?\∞駂e伋<'$H趇揑?社K+[珡扛|邈扶鸹 旷牛i蜢幂軳撤綪葙匍С骛?涢藁麌矿汳Z旻局 9wMO-?w蟓Q帔L<褉趎礥郎1?橎＃銴O]茍 n^毃砊=u?VN遉㏑{UC嫏R.翍 抡S\I悯BA爦?y孎鶔釔f蕴葹?蠧}Ty{ 毃g燌/仑慄R?ミ鵵2孢γ-L丅f干玄缦mO眤'{?囘}镛禎蔑??旷皮s呿鸊]殯w牾h遉?缚縭f柍?圻顁咇]R鐜<1怿MJ擳 隢駀[+t郣颙欍>&鎷阑t0捀9牤吮銰蹁崇?禘韖?雔 喂婟1 ┰%迿帔俫摛@媔I_mI Gn$蜠{酖淔仭v叮`虝Nc?7靶QD遍a/v椫侄8N假琕嬙h タ/~洴s?XYSA2j%瞆[兀Z緯x鸑k繜嘬 卫掛&霘I]瘕o|鉡g/^zn鎶+?K遱賨gz鬀跖?鸧bX ;?妎 ]ズ_T>捥8 雄镾?跗 2?馐 ?`sq 朦爋苻屺椾c[kX烰| 甁bL0 ri%@ㄌ伊b釷箭?/諙?@顭嗒GJ荣]呸Q 潾-?u';?Pk驿詙 枲5J鲥Lui祾￣xs眾戊\箕卂u轊怉sw5q鏳兵渔谄 y柎剄潥J畅钔?o蓊|HA DHrs??敘|憌m樨xA枃?!酛桱K4n鸿2.m雴u軤l役0E淿T?:l噪 |\鎬輵諣L捦糣唙F垻婣靓傧O婨鶏_銔7啘昩[YX?nomCL;HNN潻.畃偻Mr※l逄?ΖL\邷︱k礿蚖棐殪鹢+V/<漺魁卂?]鲠 ah反牪v;yg/8J&T|毆7?,Tt\驽g峈6蚒?駲熿7??卓\ K[絉塒tiu儼闾謾FVU0C穅顢c瘱 正泾驺O&娕'瀥b{嵪V蟔8曼漎] 琴阝鲻瞩鬟絳缙r篼穙紼Xm甃?巾U釢HwA$sU枑胓俊受訲@ ?樨He?瘙*{ ?怮KD$侘'@=諥rc眆 iV訣{鄃'>?QW5!??凾]肽;9嫣踃軇坐O粐苋Q斒T毱Ci銉掚顅c\乤b?U豪ーk魁k鰇啉Ro?犳@趨匛並絠js?渠?^:康sN? 蚰舠+ +衾qscm|p躖Y霛媑稚cV侄螡]=竪n~沖葙鶂听喑-W蔗8诶鈪寶碝犀儰k晩 靴~垯M砚[t﹛Z橢蠜?$?EM帰 癕B饝.砱?XE nJy拻U伴聲 БjPmB諄&v窻,r?巇;:&?Z'筡R洧陁 s惆 }?都QTh鬣尥?騥_婕k2黜伥k誃礡Q7孿i*#!hd 雋+IH繑席/?搾<濸??(?tcmqcc峜8H 赛羶擘EVB?J棏?{鴴欑CgP?票:6DYb縔[\v"?4蔯璨阣キRb! m瑁BS峵IO匢 焕U︴.忱ベ焗?G$憭P}纠bwＦ3轪+關Р籜図狣饆 1N(~喎3?竪5p崚h鲢經砥}rp腹隆a蝖{8粤@k嶶UG/038$3?桄X瓡蟻:硥?n吆v龛}菊C羓X鸓抓脌GS柃篽 籎*癴%S瀺!Un葏&*T?嘎戝=*t?％盧ぜ蚞迉t窮ㄠ$臂抒気篆%承nEZ n賴0d岤m 喝梛mP.＝玭Z钄氌?}\∞柬?┈鈉m洽]:袼癤蠋p葵給6凃]N8鶾鮜p炮B盶?&?D爨@[?3螚)?筪5桙緖?_祂o裯 S9潼L 书(t抔玄?7%衳◤婫劜?J驯6靺.桯軕`竚赮篼P攀硔嘅軎< 砂 荷w&@傾衟癓€帹髦>H` oā禦榠焇z斮r呪[O腓輽銿襔8鄎鞰?=舶V2裮忿z雿{;b梐 税,闹 ?輕kk絑,便鬓^#?祻泟灆乺 K`鐀货嗥輀飢餡鴧飺€s潵ア.4s?豪搯威昂鉩D 瀋?譮?嚘眐N:n泱y匁(lRvP1!?W 掿*f?q驢G赈絺?T呵=射?9  櫋 ?i 岔嬚潃宒X塮祼鏯.`8a=&铸o榫'*H鍻暳昕瓸鬚o€媑+湺f?摞牨w5荫灘 瞿仟$?7蜵:峲>3る圻|W臂€宧}o黟n诀裲薷X⒚U Bi娎檴??宛u誦鼐甁瑎菂d\W>︽0攤ksfT唑82彖F掦?鎦f [ふmF6 ?理*@酛唗猦赚侺崢D隺閹0熷?"耏水媡鱌$cPU宺'.浣笧D'蓆pOm遦褌Zu&OCJ癩?x辊艴. h惟亜_h諌wtG冔穙p4s)摵y絰遪=肪|礞垤A庤W?攩bW)wNG蛖n| i鄈U3?|`摿r? w晕楞婰?単Vo 臩& 4犚廥 墬$X!KR邈:書埨彸a摖 ?|P撀萈Uh2YK襕j5l2Xm碛鮌?d?匎:J拰 磳擥u>I)蘍砍飊甈檇K[a澀ja!?8<~o纩鞹W鰒罹髁蚇筻鰢颺{颷鼢n⑹賵tq篫`beO斆R17鐱粐脗砅 ㄣX〝疔l2募匦蒜?9L|Z厶渵}b鉉 G.^O5!? +涡7岽CT9#YN  €kw涢蓂Mj谮ǜF_赗`\弫S 鉟铅榗[yL?癃o櫕韸N┆軳?樉|馕絒葵;縱胼R=巤S€攄2背{?-TV稏7/p蛞~籗;籕o芑y慊U 筨蚳0?J?)鐐B$怢↙C r橁aCヂd蚪Ｐ鸆}畍0?$Q?2c\?灦V1I⑦-q蠆,ㄚ銚Dw8?lK侄架*Q傟睺戳L薧X?颞轕韛瀀>长識?W%.啠?}鱰a?:塜?04椒{?熯谮辭 +)鲅曠?Z??捀wn紈韠_?V璚nF -nru:纪?颠-6J閅e锿イ竣?貽ユ糙码趾B>o)xE??w楝rj岨-em遻,4IEND瓸`D猩陏寕K haofangcn@sdu.edu.cn嗌陏寕K Pmailto:haofangcn@sdu.edu.cnyX侓;H?俔膮'cカW$$If!vh55n#v#vn:V杔655nW$$If!vh55n#v#vn:V杔655nW$$If!vh55n#v#vn:V杔655n[$$If!vh55n#v#vn:V杔攤655nW$$If!vh55n#v#vn:V杔655nJ@?J ck噀 $1$a$ CJKH_HaJmH nHsH tH\@"\ h槝 2$1$@&[$\$a$5丆J$KHOJQJ\乛JaJ$X@BX h槝 4$1$@&[$\$a$5丆JKHOJQJ\乛J$A@?$ 貫祂=刉[SOBi@?B nf恏圏h4 l4a k? 鄀Rh"W@" P-x亯筽5乗 﨩 P-xjrnl0U@0 厤7€>*S*€Y(phT^@"T nf?Q賨)$1$[$\$a$CJKHOJQJ^J"X@1" :_6乚乗﨩?B\ Default1$7$8$H$%B*CJ_HaJmH nHphsH tHjp@Sj €{f媁 2:Vj?佒呏喼j?傊 呏喼j?呏喼j?€ 呏喼j?呏喼j?佒呏喼 $1$a$O吺5\吺5\吺5B*\`Jph吺5\吺5\吺5\wN&(3TrUV`):€rs€2)*<; b cq1stvy0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€0€€80€€80€€8€€8€€80€€80€€0€€ 0€€ 0€€ 0€€ 0€€ 0€€ 0€€ €€ 0€€ 0€€ 0€€ 0€€ 0€€ 0€€ 0€€ 8€€0€€€0€€0€€€80€€€€€€€€80€€80€€€€€€€€€€€€0€€0€€€€€€€€€€€€€€€€€€€€€€0€€0€€0€€&(3TrU`)€rs€<; b cq1sty欯0€€欯0€€欯0€€欯0€€欯0€€欯0€€欯0€€欯0€€欯0€€欯0€€欯0€€{00!€{00€{00€{00#€{00!€{00(屷{00{00({00&{00{00&{00&{00{00&{00&{00{00&{00&{00{00€{00€{00€{0"0€K00€{0"0€{00€{00€{0"0€{00€{0*0+$,\{0*0{00€燍%0"0€K00€K00€K00€{0/0 燍%0'0€K00€K00€K00€K00€K00K00€   \18@繞釧睟菴鐲"#$%&) r D鐲鐲IwX€X餷?b?馃煷j?Y梮陖纋χo{2N@€€€?鹇?  饖  S 餖A兠. PP覵`T覵`TP"`養 S  ?&wP擛&f溳<g\唿h唿i苻<j溵<k蔹l\帱m茚<n帱o\蔹p茌<q溹<r茑<s\狳t狳u溼<v溰<w\埸x苘<y溾<z茆<{恻|\恻}溿<~茔<泓€\泓侙滀<傴茕<凐潼匄\潼咗滃<嗻苠<國妩堷\妩夬滄<婙苕<孁纥rr{XXlXX`fS^hhv!!t t } y     !"#$%zjtt_eppZfr~~&&| y    !"#$%9*€urn:schemas-microsoft-com:office:smarttags€State€=&*€urn:schemas-microsoft-com:office:smarttags €PlaceName€=$*€urn:schemas-microsoft-com:office:smarttags €PlaceType€8*€urn:schemas-microsoft-com:office:smarttags€City€9%*€urn:schemas-microsoft-com:office:smarttags€place€B*€urn:schemas-microsoft-com:office:smarttags€country-region€>*€urn:schemas-microsoft-com:office:smarttags €PersonName€ $X€Cao J €ProductID&%$%&&$%&&$%&%$&%&$%&$$$&%$&%&%$%"$   TV`28=D%&1   % 0 6 i s pz#+2:oswz qrt 47  LPW[^bdfhqyTV_`e?CC } 4 a b _cJ<Nq  KLQy333333333333333333(3UV`):s*<  n 4 b <cMqLuyy嶴`n](*64H:KLecdtufP-x鄜鴈?AbGH旵鯟i 繯&'(UV):€rs€ b y{?0{?0{?0{?0{?0@€€  p22 w@@@@@$@@@,@@@4@@€@UnknownG:郃x Times New Roman5€Symbol3& :郈x ArialkTimesNewRomanPSMTTimes New Roman;?媅SOSimSun;5 wiSO_GB2312;5 N媅_GB2312 qh酪噓篝 ? ! !!-!),.:;?]}    & 6"0000 0 000000  =@\]^?([{  0 0 00000;[??個2nn2僸HX)??嶴2筫im q\N'Yf[o僨[b杘僫rSf[NNYe坈0ZS隭u黐^thinkthink?鄥燆鵒h珣+'迟0  0< \ h t€4方浩： 888集团官网最新版药物化学专业教授、博士生导师thinkNormalthink11Microsoft Office Word@:@h@沮j@F?^?胀諟.摋+,D胀諟.摋+, X`lt| ! n D 8@ _PID_HLINKSA #7,http://www.ncbi.nlm.nih.gov/pubmed/22506769xmailto:haofangcn@sdu.edu.cn  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcd?fghijkl?nopqrstuvwxyz{|}~€????????Root Entry FP54D^€Data e1TablemP-WordDocument∩SummaryInformation(DocumentSummaryInformation8CompObjm??  FMicrosoft Office Word 文档 MSWordDocWord.Document.8?瞦